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Secure Email Gateway Software with Two-Factor Authentication (2026)

Last updated: April 2026

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39 software options

Libraesva Email Security logo

Libraesva Email Security

Exceptional Email Security

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Libraesva Email Security stops known and emerging email threats from reaching their target, so you only receive legitimate messages. It provides exceptional email security by integrating cloud email and a secure email gateway with Libraesva’s unique Adaptive Trust Engine.

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Virtru logo

Virtru

Cloud-based data privacy and security platform

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Virtru offers a range of data protection products that provide encryption, access controls, key management, and persistent audit to meet security and privacy needs. Supports HIPAA, GDPR, CCPA, ITAR, CJIS, NIST, FERPA and CCMC compliance & integrates seamlessly into the platforms you already use.

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Sentry Email Defense Service logo

Cloud-based email protection platform

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Sentry Email Defense Service (EDS) is a cloud-based platform that helps businesses ensure protection against spam, virus, phishing links, DDoS, ransomware, and various other threats. Features include real-time reporting, encryption, data leakage protection, SMTP logs, and email archiving.

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Abnormal AI logo

A Fundamentally Different Approach to Email Security

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Abnormal provides total protection against the widest range of attacks including phishing, malware, ransomware, social engineering, executive impersonation, supply chain compromise, internal account compromise, spam, and graymail.

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Paubox Email Suite logo

HIPAA-compliant email encryption software

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Paubox Email Suite is a HIPAA-compliant email encryption software designed to help businesses manage and secure emails using encryption and data loss prevention methods. It includes ExecProtect, which allows businesses to prevent data breaches, phishing, and display name spoofing attacks by automatically detecting and blocking impersonation scams and informing administrators via emails.

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Trustifi logo

Protect Your Business Emails with AI-Powered Security

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Email security solution that helps manage threat detection, regulatory compliance, data encryption, whitelisting/blacklisting, and more.

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Security Gateway by MDaemon logo

Powerful yet flexible email security software.

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Security Gateway by MDaemon is an email security software designed to help businesses secure email servers from malware and phishing attacks. The solution enables administrators to automatically detect threats across various platforms including Microsoft Exchange Server and Office 365.

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ContentCatcher logo

Cloud-based email security, phishing protection & anti-spam

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ContentCatcher is a web-based SaaS solution offering email security, encryption, anti-spam, phishing protection and compliant archiving to assist organizations of all levels to combat and mitigate malicious email threats, with features including anti-virus, filtering, URL defense, reporting and more

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NeoCertified logo

Secure email for confidential & sensitive documents

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NeoCertified provides secure email encryption with Outlook integration for businesses of all industries, including healthcare, finance, legal & education

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SMTP2GO logo

Fast, reliable mail delivery and management solution

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SMTP2GO is a cloud-based email management solution which helps businesses track emails and generate visual reports. Key features include data management, email monitoring, blacklisting, email authentication, and an API.

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Delivery Trust logo

Email Encryption Platform

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Delivery Trust is a user-friendly secure email solution to protect critical information.

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Avanan logo

Email Security — Reinvented

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Avanan catches the advanced attacks that evade default and advanced security tools. Its invisible, multi-layer security enables full-suite protection for cloud collaboration solutions such as Office 365, G-Suite, and Slack. The platform deploys in one click via API.

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Sealit logo

Full Security - Just 1 Click.

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Sealit protects your data, no matter how it's shared. End-to-end email and file encryption for small businesses or individuals.

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Selzy logo

Affordable email marketing software

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Selzy is an intuitive email marketing platform that suits any business needs. It offers a wide range of integrations with your favorite tools, an easy-to-use drag&drop editor, and email templates for any occasion.

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ALTOSPAM logo

Effectively protect all your company's emails

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ALTOSPAM is an email protection solution for all businesses, associations and local authorities. Choose advanced email security compatible with all mail servers, including Office 365. Try ALTOSPAM for free.

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Zerospam logo

Cloud email security & anti-spam solution

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ZEROSPAM is a complete cloud email security and anti-spam solution that protects domains against spam, ransomware, spear phishing, viruses, phishing and all harmful emails. Detect disguised executable files & infected macros sent as attachments via emails or downloaded through a malicious link.

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Sophos Email logo

Software for managing email encryption and secure networks

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Sophos Email is a cloud-based software designed to help businesses establish secure email networks and ensure protection from malware, intrusion, unauthorized access, and other online threats. The application includes anti-ransomware technology, which enables organizations to stop boot-record and ransomware attacks using behavioral analysis.

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365 Total Protection logo

Email security management for Microsoft Office 365

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365 Total Protection is an email security & compliance solution for Microsoft Office 365 with features for tracking emails in real time, handling infomail, blocking spam, filtering for compliance, defending against threats, black & whitelisting, archiving emails, analyzing communications, & more

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Mailock logo

Secure emails with encryption and recipient authentication

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Exchange confidential information securely with the Mailock Enterprise secure email gateway. Encrypt messages and authenticate recipients.

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IRONSCALES logo

We catch the phish that others miss!

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We ensure your inboxes are uncompromised and your team is unburdened.

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modusCloud logo

Cloud email security, encryption, and archiving

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modusCloud is a cloud email security solution with tools for spam detection, threat monitoring, email archiving, phishing detection, and more. The cloud-based platform offers features including filtering, continuity, encryption, and archiving in order to provide businesses with email protection.

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Secure Exchanges logo

Protect data with point-to-point encrypted email exchange

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The fully integrated & easiest secure technology to exchange, retrieve or sign confidential documents up to 2.5G. It doesn't require any change in its users behavior or server migration.

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Cisco Secure Email logo

Cloud-based email security tool for preventing cyberattacks

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Cisco Secure Email is a cloud-based email security software designed to help businesses of all sizes provide protection against malicious files, malware, ransomware, phishing attacks, spoofing, and other cyber threats. It enables organizations to streamline data loss prevention (DLP) and encryption processes to safeguard critical business information.

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SpamTitan logo

Anti-spam filter for business email. Vital email security.

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SpamTitan is an anti-spam email security solution that identifies & blocks phishing, malware, spear phishing, malicious and spam emails to protect business email, with multi-layered analysis and authentication. 5 Star product with great pricing and amazing front line support

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Zoho Mail logo

Zoho Mail is a secure, encrypted, and enterprise-ready email

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Zoho Mail, a business-oriented and privacy-guaranteed email service, is your single email solution. Zoho Mail also comes bundled with modern collaborative tools and a suite of apps to meet your business needs. Migrate now and get your unique email address with Zoho Mail.

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