OpenClinica - 2026 Pricing, Features, Reviews & Alternatives

OpenClinica is an Enterprise-level electronic data capture (EDC) and management solution designed to meet the needs of clinical researchers. The single, all-in-one platform provides HIPAA compliant online deployment, offering 256-bit encryption to secure centralized data and claim ISO 9001, 27001 certification. From here, OpenClinica spans integrated modules across not only EDC and specifically clinical data management, but also the addition of randomization to studies, supply management, patient reported outcomes (ePRO & eCOA) and also reporting.

Using OpenClinica's collaborative designer, users can create studies and mobile optimized forms for every site and subject. Electronic case report forms (eCRFs) can be generated with additional features including editing checks in real time, field skipping logic and also automatic saving. Drag and drop editing allows for intuitive definition, ordering, and re-arrangement of events and forms, while audit logs ensure safe collaboration thanks to audit logs and versioning. Forms can be previewed authentically within the system, with sharing among study managers also facilitated via custom permissions. Data capture is then assisted by batch upload or API-based connectivity with existing systems, before patients and participants are able to engage and make submissions directly from any web-enabled device. Notifications send gentle reminders to participants via SMS or email to prompt engagement, while monitors can keep track of site activities from the field with access to a mobile optimized dashboard. OpenClinica also incorporates integrated reporting functions, providing bar chart and line graph visualizations for operational and clinical data which can be scheduled for sending as report updates to team leads.