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Anti-spam Software for Large Enterprises (2026)

Last updated: March 2026

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52 software options

ContentCatcher logo

Cloud-based email security, phishing protection & anti-spam

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ContentCatcher is available for Large Enterprises and offers the following support options: Email/Help Desk, 24/7 (Live rep), Phone Support.

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Heimdal Email Security logo

Email Protection in a Redefined Spam Filter

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Heimdal Email Security is available for Large Enterprises and offers the following support options: Email/Help Desk, Knowledge Base, FAQs/Forum.

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ESET Endpoint Security logo

Network security, network monitoring & endpoint protection

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ESET Endpoint Security is available for Large Enterprises and offers the following support options: Email/Help Desk, Chat, Phone Support.

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SpamTitan logo

Anti-spam filter for business email. Vital email security.

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SpamTitan is available for Large Enterprises and offers the following support options: Email/Help Desk, Chat, Knowledge Base, FAQs/Forum, 24/7 (Live rep), Phone Support.

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Microsoft Defender for Office 365 logo

Cloud-based email security and threat management software

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Microsoft Defender for Office 365 is available for Large Enterprises.

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Zerospam logo

Cloud email security & anti-spam solution

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Zerospam is available for Large Enterprises and offers the following support options: Knowledge Base, 24/7 (Live rep), Phone Support, Email/Help Desk.

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Malwarebytes for Teams logo

Advanced malware protection for small businesses.

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Malwarebytes for Teams is available for Large Enterprises.

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Symantec Email Security.cloud logo

Anti-spam and email security software

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Symantec Email Security.cloud is available for Large Enterprises and offers the following support options: Email/Help Desk.

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Topsec Cloud Solutions logo

Your Managed Email Security Specialists

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Topsec Cloud Solutions is available for Large Enterprises and offers the following support options: Knowledge Base, 24/7 (Live rep), Phone Support, Email/Help Desk.

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ALTOSPAM logo

Effectively protect all your company's emails

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ALTOSPAM is available for Large Enterprises and offers the following support options: 24/7 (Live rep), Chat, Email/Help Desk, FAQs/Forum, Knowledge Base, Phone Support.

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Avanan logo

Email Security — Reinvented

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Avanan is available for Large Enterprises and offers the following support options: FAQs/Forum, Phone Support, Email/Help Desk, Chat.

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LeanMail logo

Don't give up finding a solution for email until you try LM

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LeanMail is available for Large Enterprises and offers the following support options: Email/Help Desk, FAQs/Forum, Phone Support, 24/7 (Live rep), Chat.

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Truecaller logo

Spam Blocking and Caller ID

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Truecaller is available for Large Enterprises and offers the following support options: Knowledge Base.

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McAfee Security for Email Servers logo

Cloud-based email security platform

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McAfee Security for Email Servers is available for Large Enterprises and offers the following support options: Knowledge Base.

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Trend Micro Smart Protection Complete Suite logo

Security and threat management solution

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Trend Micro Smart Protection Complete Suite is available for Large Enterprises.

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IPQS logo

Fraud prevention solution for proactively detecting fraud

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IPQS is available for Large Enterprises and offers the following support options: FAQs/Forum, Knowledge Base.

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MailCleaner logo

Cloud & on-premise anti spam software for businesses

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MailCleaner is available for Large Enterprises and offers the following support options: Phone Support, Email/Help Desk, Chat, FAQs/Forum, Knowledge Base, 24/7 (Live rep).

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Mail Assure logo

Email, Secured.

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Mail Assure is available for Large Enterprises and offers the following support options: Knowledge Base, Email/Help Desk, 24/7 (Live rep), FAQs/Forum, Phone Support.

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Trustifi logo

Protect Your Business Emails with AI-Powered Security

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Trustifi is available for Large Enterprises and offers the following support options: Email/Help Desk, FAQs/Forum, Knowledge Base, Phone Support, Chat.

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Radware Bot Manager logo

Automated bot detection for websites and mobile apps

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Radware Bot Manager is available for Large Enterprises.

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Cisco Secure Email logo

Cloud-based email security tool for preventing cyberattacks

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Cisco Secure Email is available for Large Enterprises and offers the following support options: Chat, 24/7 (Live rep), Phone Support, Knowledge Base, FAQs/Forum, Email/Help Desk.

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Security Gateway by MDaemon logo

Powerful yet flexible email security software.

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Security Gateway by MDaemon is available for Large Enterprises and offers the following support options: Chat, Email/Help Desk, FAQs/Forum, Knowledge Base, Phone Support.

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INLYSE Malware.AI logo

VISUAL AI BASED MALWARE DETECTION

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INLYSE Malware.AI is available for Large Enterprises and offers the following support options: Email/Help Desk, FAQs/Forum, Knowledge Base.

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ESET PROTECT MDR logo

Future ready protection for enterprise

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ESET PROTECT MDR is available for Large Enterprises and offers the following support options: 24/7 (Live rep), Chat, Knowledge Base, FAQs/Forum, Email/Help Desk, Phone Support.

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Spam Filtering and Malware Protection logo

Spam filter service for email inboxes

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Spam Filtering and Malware Protection is available for Large Enterprises and offers the following support options: Phone Support, Email/Help Desk, FAQs/Forum, 24/7 (Live rep), Knowledge Base.

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