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Top Rated e-Prescribing Software with EPCS Compliant

Last updated: April 2026

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23 software options

DxScript logo

DxScript

HIPAA compliant prescribing solution

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DxScript/+EPCS is a HIPAA compliant, Surescripts and EPCS certified, cloud-based ePrescribing solution that puts insurance, pharmacy benefits plan eligibility and formulary information at the provider’s fingertips at the point of prescribing.

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MDToolbox-Rx logo

MDToolbox-Rx

Surescripts & EPCS certified e-prescribing system

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MDToolbox e-Prescribing is a Surescripts & EPCS certified e-Prescribing software which can be used standalone on desktops, tablets, or phones, or integrated

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ScriptSure logo

ScriptSure

Electronic prescribing software

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ScriptSure is a medical software for doctors, clinics and hospitals which supports e-prescribing, EMR management, appointment scheduling technology, and more

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PracticeSuite logo

PracticeSuite

Cloud-based Medical Billing & Practice Management platform

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PracticeSuite's e-prescribing platform enables providers to safely and securely transmit prescriptions to over 70,000 pharmacies, without having to navigate away from the patient's encounter in the EMR, meeting regulatory requirements while improving medication adherence.

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CharmHealth logo

CharmHealth

AI-based healthcare platform for medical practices

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CharmHealth is an AI-based healthcare platform offering electronic health records, practice management, and medical billing solutions for medical practices of all sizes. The system features an AI scribe that automates documentation during patient encounters and integrates with pharmacies, labs, and devices. The platform includes patient engagement tools that allow individuals to schedule appointments, access records, and manage their healthcare information.

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RXNT logo

RXNT

Cloud-based Practice Management, EHR, and eRx Software

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RXNT's cloud-based E-Prescribing solution is EPCS-certified and allows providers to easily, accurately write prescriptions from anywhere. Streamline your practice with a seamless connection to our EHR, and get instant access to medical and prescription history from a single platform.

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Enablemypractice logo

Cloud-based EHR solution for medical professionals.

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Enablemypractice is an EHR (electronic health record) solution, which helps small to large healthcare organizations manage patient engagement, online billing, appointment schedules, medicine databases, and more. The platform provides several features such as communication tools, visit management, artificial intelligence (AI), reporting, electronic prescriptions, chronic care management (CCM), custom templates, live chat, mobile application, and bed management.

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SecureRx logo

Cloud-based print management software for healthcare clinics

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SecureRx is a print management software designed to help healthcare organizations and ambulatory facilities create & securely print medical prescriptions in compliance with the state & federal regulations. Users can add anti-alteration watermarks in documents & serialize prescriptions for auditing.

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TriMed Complete logo

EHR, PM, Portal, Mobile, Check In Module, & Telehealth

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TriMed offers a complete software suite that includes: EHR, Practice Management, Patient Portal, Mobile, Digital Check-in and Telemed.

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DocVilla logo

Medical Practice Management Software

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DocVilla: transform your independent medical practice with a comprehensive suite of Cloud-Based EMR and EHR software, telemedicine, e-prescribing, lab integration, Fullscript, analytics, POS, Patient portal, and inventory management. Secure, efficient, and hosted on Google Cloud and AWS.

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iCare logo

Focus on patient care, not software.

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iCare is a cloud-based medical scheduling solution, which helps small to large healthcare organizations manage patient care plans, electronic health records, lab results, and more. The platform offers various features such as custom workflows, financial insights, compliance management, third-party integration, and pre-made templates.

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H2H DigitalRx logo

by H2H Solutions

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H2H Digital Rx is a surescript-certified HIPAA-compliant cloud-based e-prescribing solution that helps healthcare professionals manage patient medication history, formulary, and refills. Features include EPCS, PDMP, RTPB, EPA, favorite Drugs, prescription templates, and many more.

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OptiMantra logo

EMR and practice management solution

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OptiMantra is a practice management and EMR solution specifically created for integrative and wellness practices.

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Nexus EHR logo

Modern, Certified EHR with Native AI & Rapid Rx

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Secure medication management with Rapid Rx. Import 2 years of Surescripts history instantly. Features fully compliant EPCS/PDMP integration, automated pharmacy search, and smart "favorites" lists for rapid-fire prescribing with real-time safety alerts.

Read more about Nexus EHR

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Qualifacts Insync logo

Cloud-based EHR and practice management software.

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Our EMR integrated e-prescribing is mobile-friendly for ease of access. Features include Eligibility and Formulary Checks, Medication History, EPCS, ePA, RTPB and APPRISS Integration for PMDP Checking. The end result is more accurate, easily-filled prescriptions for you and your practice.

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Treat logo

Standalone, ePrescribing solution for medical practitioners

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Treat is an ePrescribing solution that allows medical practitioners to send electronic prescriptions to manage patient care and streamline clinical operations. Users can select specific drugs according to patient diagnosis and add digital signatures to generate prescriptions.

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DrChrono logo

Cloud healthcare management platform

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DrChrono is a cloud-based healthcare platform that integrates electronic health records, practice management, and medical billing functionalities. The system offers customizable clinical notes, telehealth capabilities, and specialty-specific templates for medical practices of various sizes. DrChrono provides mobile accessibility through iOS apps, allowing healthcare providers to manage patient care from multiple devices.

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ChartLogic EHR logo

Cloud-based EHR solution for hospitals and clinics

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ChartLogic is an integrated electronic health recording (EHR) solution offering benefits of electronic medical recording (EMR), practice management and medical billing services in a combined suite. The solution helps to streamline clinical operations and ensures paperless workflow.

Read more about ChartLogic EHR

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DoseSpot logo

ePrescribing platform

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DoseSpot is an ePrescribing software that helps clinicians deliver safer patient care within prescribing workflows. This cloud-based UI offers two integrations to choose from and the ability to access DoseSpot’s unique APIs.

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CarePaths EHR logo

E-Health Records & Practice Management System w/ Telehealth

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ONC-Certified & HIPAA compliant cloud-based EHR and practice management platform with telehealth. Accept e-referrals, FREE claim submissions, online payments, E-statements, online scheduling, appointment reminders, clinical documentation, customizable forms, secure messaging, outcomes monitoring.

Read more about CarePaths EHR

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Practice Fusion logo

Cloud-based electronic health record platform

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Practice Fusion is a cloud-based electronic health record management solution offering features such as e-prescription, charting, scheduling and lab integration

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MicroMD logo

Cloud or on-site Practice Management, EHR, and eRx Software

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Henry Schein MicroMD provides simple, customizable practice management and 2015 ONC Certified Electronic Medical Records & e-Prescribing software.

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OrderConnect logo
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E-prescribing software with real-time interaction checking

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OrderConnect is a web-based electronic prescribing software designed to help businesses in the healthcare industry view the current medication profile of patients with primary diagnoses and known allergies. The platform lets teams pull up patients' complete medical history using devices across multiple locations.

Read more about OrderConnect

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