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Top Rated Secure Email Gateway Software with Large enterprises - Page 2

Last updated: September 2026

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38 software options

MimeCast Email Security logo

Cloud-based email security and threat intelligence platform

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MimeCast Email Security is a cloud-based secure email gateway designed to help businesses in healthcare, IT, legal, financial services, manufacturing, and other industries protect conversations from malware, spam, ransomware, spear-phishing, and zero-day attacks. Supervisors can monitor, detect and remediate internal threats by inspecting internal emails for malicious attachments, links, or confidential information.

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Proofpoint Core Email Protection logo

Secure email gateway management and threat intelligence tool

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Proofpoint Email Protection is a computer security management software designed to help businesses identify and block threats using AI-enabled tools. It offers an advanced business email compromise (BEC) defense feature, which enables administrators to analyze various attributes including message header and senders’ IP address.

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Inxmail logo

Email marketing software to create newsletters & emails

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Inxmail is the service-oriented tech specialist for secure, data-driven communication in email marketing.

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EuropeanMX logo
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Cloud-based anti-spam for incoming and outgoing messages

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Use the cloud redundancy solution EuropeanMX as a reliable spam filter. Our system offers nearly 100% filter accuracy and virtually no false positives. Protect your IP ranges before getting blacklisted. Continuously archive your emails with EuropeanMX to always have a backup of your emails.

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MailHippo logo
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HIPAA compliant email management platform

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MailHippo is the easiest way to securely send and receive sensitive information and attachments by email. All 100% HIPAA Compliant.

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SendGuard for Outlook logo

Governance, Risk & Compliance Solution for Outbound Emails

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SendGuard for Outlook prevents accidental data loss caused by misdirected emails and mis-attached files.

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Brightsquid logo

Cloud-based patient engagement software

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Brightsquid is a cloud-based patient engagement software that helps businesses monitor privacy compliance, prevent online breaches, and block cyber attacks such as ransomware or phishing.

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Microsoft Exchange logo

Secure, business-class email boosts productivity.

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Microsoft Exchange helps increase user productivity while protecting data. It offers a personalized inbox, enhanced search, customization with Add-ins, and a calendaring system that goes beyond scheduling.

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Area 1 logo
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Secure email gateway and anti-spam software

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Area 1 Horizon is a network security management software designed to help businesses protect systems against phishing attacks across various traffic sources including emails, web pages, and networks. The platform enables administrators to receive notifications about blocked phishing campaigns on a unified interface.

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RMail logo

RMail®, track, prove, encrypt, e-sign, certify, all-in-one.

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RMail® is the e-security platform by RPost®. RMail specializes in elegantly easy to use email encryption for privacy and compliance, e-signatures, legal e-delivery proof, secure file sharing, email impostor protection, and AI-infused services to prevent data leaks and human e-security errors.

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Xcitium Endpoint Detection & Resonse logo

Gain full context of a ransomware attack

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Xcitium's Endpoint Detection and Response (EDR) platform, also referred to within the cybersecurity industry as Endpoint Detection and Threat Response (EDTR), represents an advanced endpoint solution designed for the continuous monitoring of endpoint devices. This solution aims to detect and respond effectively to a wide array of major threats, including but not limited to malware and ransomware.

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FactorX.ai logo
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AI-powered email security for modern threats

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FactorX.ai is an AI-native email security platform designed for Microsoft 365 and Gmail. It uses real-time threat detection and behavioral AI to stop phishing, malware, BEC, and ransomware.

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MXGuardian logo

The Experts in Email Security

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Cloud-based email spam and malware filtering service that protects your business from phishing attacks, viruses, spam, ransomware and other email threats.

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