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e-Prescribing Software with EPCS Compliant (2026)

Last updated: April 2026

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Why is EPCS compliant important for e-prescribing software users?

Based on GetApp's analysis of verified user reviews collected between July 2021 and August 2024.

EPCS compliance ensures secure and legal prescribing of controlled substances, enhancing patient safety, adherence, and workflow efficiency. It meets regulatory requirements, reduces fraud, and facilitates multifactor authentication for added security. Of the 69 reviewers who rated EPCS compliant, 93% rated this feature as important or highly important.

Key features of e-prescribing software based on insights from 569 verified reviews

  • HIPAA Compliant: Reviewers emphasize the importance of secure patient data handling, encryption, and adherence to federal regulations for privacy protection. 97% of reviewers rated this feature as important or highly important.
  • Prescription Renewal: Users find prescription renewals easy and efficient, with helpful alerts and quick reordering processes improving workflow. 95% of reviewers rated this feature as important or highly important.
  • Medication History: Reviewers value seeing comprehensive patient medication records, aiding in accurate prescribing and reducing risks of polypharmacy. 93% of reviewers rated this feature as important or highly important.
  • Charting: Reviewers highlight customizable templates and ease of use, which improve efficiency and meet specific practice needs. 92% of reviewers rated this feature as important or highly important.
  • Medication Alerts/Warnings: Users find medication alerts useful for enhancing patient safety by flagging potential drug interactions and contraindications. 90% of reviewers rated this feature as important or highly important.
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23 software options

Qualifacts Insync logo
Category Leaders

Cloud-based EHR and practice management software.

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Our EMR integrated e-prescribing is mobile-friendly for ease of access. Features include Eligibility and Formulary Checks, Medication History, EPCS, ePA, RTPB and APPRISS Integration for PMDP Checking. The end result is more accurate, easily-filled prescriptions for you and your practice.

Read more about Qualifacts Insync

Users also considered
RXNT logo
Category Leaders

Cloud-based Practice Management, EHR, and eRx Software

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RXNT's cloud-based E-Prescribing solution is EPCS-certified and allows providers to easily, accurately write prescriptions from anywhere. Streamline your practice with a seamless connection to our EHR, and get instant access to medical and prescription history from a single platform.

Read more about RXNT

Users also considered
MDToolbox-Rx logo
Category Leaders

Surescripts & EPCS certified e-prescribing system

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MDToolbox e-Prescribing is a Surescripts & EPCS certified e-Prescribing software which can be used standalone on desktops, tablets, or phones, or integrated

Read more about MDToolbox-Rx

Users also considered
DrChrono logo

Cloud healthcare management platform

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DrChrono is a cloud-based healthcare platform that integrates electronic health records, practice management, and medical billing functionalities. The system offers customizable clinical notes, telehealth capabilities, and specialty-specific templates for medical practices of various sizes. DrChrono provides mobile accessibility through iOS apps, allowing healthcare providers to manage patient care from multiple devices.

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DocVilla logo
Category Leaders

Medical Practice Management Software

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DocVilla: transform your independent medical practice with a comprehensive suite of Cloud-Based EMR and EHR software, telemedicine, e-prescribing, lab integration, Fullscript, analytics, POS, Patient portal, and inventory management. Secure, efficient, and hosted on Google Cloud and AWS.

Read more about DocVilla

Users also considered
OptiMantra logo

EMR and practice management solution

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OptiMantra is a practice management and EMR solution specifically created for integrative and wellness practices.

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TriMed Complete logo

EHR, PM, Portal, Mobile, Check In Module, & Telehealth

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TriMed offers a complete software suite that includes: EHR, Practice Management, Patient Portal, Mobile, Digital Check-in and Telemed.

Read more about TriMed Complete

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CharmHealth logo
Category Leaders

AI-based healthcare platform for medical practices

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CharmHealth is an AI-based healthcare platform offering electronic health records, practice management, and medical billing solutions for medical practices of all sizes. The system features an AI scribe that automates documentation during patient encounters and integrates with pharmacies, labs, and devices. The platform includes patient engagement tools that allow individuals to schedule appointments, access records, and manage their healthcare information.

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Practice Fusion logo

Cloud-based electronic health record platform

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Practice Fusion is a cloud-based electronic health record management solution offering features such as e-prescription, charting, scheduling and lab integration

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Users also considered
Treat logo

Standalone, ePrescribing solution for medical practitioners

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Treat is an ePrescribing solution that allows medical practitioners to send electronic prescriptions to manage patient care and streamline clinical operations. Users can select specific drugs according to patient diagnosis and add digital signatures to generate prescriptions.

Read more about Treat

Users also considered
iCare logo

Focus on patient care, not software.

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iCare is a cloud-based medical scheduling solution, which helps small to large healthcare organizations manage patient care plans, electronic health records, lab results, and more. The platform offers various features such as custom workflows, financial insights, compliance management, third-party integration, and pre-made templates.

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Users also considered
DxScript logo

HIPAA compliant prescribing solution

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DxScript/+EPCS is a HIPAA compliant, Surescripts and EPCS certified, cloud-based ePrescribing solution that puts insurance, pharmacy benefits plan eligibility and formulary information at the provider’s fingertips at the point of prescribing.

Read more about DxScript

Users also considered
Nexus EHR logo

Certified, Modern and affordable healthcare platform.

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Nexus EHR includes ePrescribing with EPCS and PDMP. Easy workflow, maintain doctors medication lists, preferred pharmacy selection for each patient from self-service.Pull surescript medication history for patients.

Read more about Nexus EHR

Users also considered
ScriptSure logo

Electronic prescribing software

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ScriptSure is a medical software for doctors, clinics and hospitals which supports e-prescribing, EMR management, appointment scheduling technology, and more

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Users also considered
ChartLogic EHR logo

Cloud-based EHR solution for hospitals and clinics

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ChartLogic is an integrated electronic health recording (EHR) solution offering benefits of electronic medical recording (EMR), practice management and medical billing services in a combined suite. The solution helps to streamline clinical operations and ensures paperless workflow.

Read more about ChartLogic EHR

Users also considered
PracticeSuite logo

Cloud-based Medical Billing & Practice Management platform

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PracticeSuite's e-prescribing platform enables providers to safely and securely transmit prescriptions to over 70,000 pharmacies, without having to navigate away from the patient's encounter in the EMR, meeting regulatory requirements while improving medication adherence.

Read more about PracticeSuite

Users also considered
CarePaths EHR logo

E-Health Records & Practice Management System w/ Telehealth

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ONC-Certified & HIPAA compliant cloud-based EHR and practice management platform with telehealth. Accept e-referrals, FREE claim submissions, online payments, E-statements, online scheduling, appointment reminders, clinical documentation, customizable forms, secure messaging, outcomes monitoring.

Read more about CarePaths EHR

Users also considered
DoseSpot logo

ePrescribing platform

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DoseSpot is an ePrescribing software that helps clinicians deliver safer patient care within prescribing workflows. This cloud-based UI offers two integrations to choose from and the ability to access DoseSpot’s unique APIs.

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Users also considered
H2H DigitalRx logo

by H2H Solutions

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H2H Digital Rx is a surescript-certified HIPAA-compliant cloud-based e-prescribing solution that helps healthcare professionals manage patient medication history, formulary, and refills. Features include EPCS, PDMP, RTPB, EPA, favorite Drugs, prescription templates, and many more.

Read more about H2H DigitalRx

Users also considered
MicroMD logo

Cloud or on-site Practice Management, EHR, and eRx Software

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Henry Schein MicroMD provides simple, customizable practice management and 2015 ONC Certified Electronic Medical Records & e-Prescribing software.

Read more about MicroMD

Users also considered
SecureRx logo

Cloud-based print management software for healthcare clinics

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SecureRx is a print management software designed to help healthcare organizations and ambulatory facilities create & securely print medical prescriptions in compliance with the state & federal regulations. Users can add anti-alteration watermarks in documents & serialize prescriptions for auditing.

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Users also considered
Enablemypractice logo

Cloud-based EHR solution for medical professionals.

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Enablemypractice is an EHR (electronic health record) solution, which helps small to large healthcare organizations manage patient engagement, online billing, appointment schedules, medicine databases, and more. The platform provides several features such as communication tools, visit management, artificial intelligence (AI), reporting, electronic prescriptions, chronic care management (CCM), custom templates, live chat, mobile application, and bed management.

Read more about Enablemypractice

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OrderConnect logo
(0)

E-prescribing software with real-time interaction checking

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OrderConnect is a web-based electronic prescribing software designed to help businesses in the healthcare industry view the current medication profile of patients with primary diagnoses and known allergies. The platform lets teams pull up patients' complete medical history using devices across multiple locations.

Read more about OrderConnect

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