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Electronic Data Capture Software with 21 CFR Part 11 Compliance (2026)

Last updated: March 2026

Key features of Electronic Data Capture Software

Based on GetApp's analysis of verified user reviews collected between July 2021 and August 2024.

  • Customizable Forms: Users value the extensive customization options for forms, including design elements and the ability to tailor forms to various business needs. 94% of reviewers rated this feature as important or highly important.
  • Data Capture and Transfer: Reviewers appreciate the diverse data entry options and seamless data transfer capabilities, ensuring efficient and accurate data handling. 94% of reviewers rated this feature as important or highly important.
  • Audit Trail: Users find the audit trail critical for tracking changes and ensuring compliance, with easy access and clear documentation of all actions. 90% of reviewers rated this feature as important or highly important.
  • Data Verification: Reviewers highlight the importance of data verification for reducing errors and ensuring data quality, with flexible monitoring and validation options. 89% of reviewers rated this feature as important or highly important.
  • Data Import/Export: Users benefit from easy-to-use import/export features, enabling efficient data management, reporting, and integration with other systems. 86% of reviewers rated this feature as important or highly important.
  • Remote Data Capture: Reviewers emphasize the necessity of remote data capture for flexibility and efficiency, especially in decentralized or remote work environments. 77% of reviewers rated this feature as important or highly important.
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31 software options

ClinCapture logo

Captivate® EDC is the most flexible tool on the market today

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Captivate® is the most intuitive and flexible eClinical tool on the market today. Request a demo to see the no code EDC!

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ShareCRF logo

EDC software for clinical research

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Take control of your clinical trial data with ShareCRF. Configure your study in hours—no coding or external help needed. Enjoy an intuitive interface, full regulatory compliance, and unmatched adaptability to fit your unique study needs. Simplicity, efficiency, and reliability in one platform.

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Flex Databases platform logo

Unified platform for handling clinical trials and documents

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Capture clinical data flawlessly. Securely collect diverse data types (text, numbers, images, signatures) with intuitive forms. Monitor quality & progress in real-time. Reduce errors & simplify workflows. Cloud & on-premise options.

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Castor EDC logo

The top-rated EDC system in the world *EDC + ePRO + eConsent

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The only GCP & 21 CFR compliant EDC that's affordable for every researcher and has all the features of expensive systems. Start now.

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Viedoc logo

Electronic data capture for clinical trials

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Viedoc delivers powerful eClinical solutions that streamline clinical trials, making data collection, management, and analysis faster and easier. Trusted in 75+ countries, powering 7,000+ studies with more than 1.6M+ participants.

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Researchmanager – Clinical Research Suite logo

EDC, CTMS, eTMF, ePRO, RTSM, eConsent, RIMS, LIMS

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The Clinical Research Suite is an online platform tailored for managing clinical trials, facilitating organizations in planning, strategizing, and executing life science research.

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Medrio logo

Powering your research potential.

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Medrio is an electronic data capture (EDC) tool for clinical research teams with tools for capturing, storing, analyzing, & managing patient data during clinical trials. Medrio offers secure storage of patient data, automates regulatory compliance management & allows users to build custom studies.

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OpenClinica logo

Driving the future of clinical trials. Better data, faster.

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OpenClinica is a compliant, all-in-one clinical data management platform offering electronic data capture with collaborative drag and drop interface for designing studies, randomization and supply management, patient reported outcomes (ePRO & eCOA), plus reporting tools with chart visualizations

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eClinPro CTMS & eSource logo

Clinical trials made simple, compliant, and efficient

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eClinPro CTMS & eSource is a clinical trial management system (CTMS) that helps research centers manage clinical studies.

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TrialKit logo

Data collection and study management platform

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TrialKit, a global, cloud-based development platform for end-to-end, "direct-from-source" data collection and workflow management across all phases of clinical trials.

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CRIO logo

Clinical research regulatory workflow management software

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CRIO, the leader in eSource technology, is a health tech company helping pharma, biotech, research sites, and academic research centers streamline regulatory workflows with one system that delivers a single source of clinical data capture.

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Prelude EDC logo

Clinical trial management system for researchers

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Prelude EDC is a web-based EDC solution that helps researchers and clinicians with clinical trial management. Key features include electronic data capture, data management, project management, custom fields, audit trail, automatic notifications, and compliance management.

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Climedo  logo

Powerful, modular and secure solutions for DCTs.

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Climedo is a secure and modular cloud-based electronic data capture (EDC) tool for decentralized clinical trials. It enables the clinical validation and post-market surveillance of of medtech and pharma products using tools such as cOA/ePRO, eCRF, clinical study tracking, input forms, etc.

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Datacapt logo

One unified Platform. Datacapt is reimagining your Trials.

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Datacapt is an intuitive and easy-to-use EDC platform with eCRF, ePRO, eConsult, and eConsent. Access real-rime reports, high-quality data capture, and fully compliant.

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CRFweb logo

Electronic data capture software for clinical trials

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CRFWEB is an electronic data capture (EDC) software that helps organizations collect, manage, and analyze clinical data in compliance with FDA guidelines. With the eCRF module, staff members can handle queries, formulas, audit logs, edit checks, and more from within a centralized dashboard.

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Data+ logo

Data management system for clinical research & bio-banks

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Data+ Research is a fully compliant & customizable application development platform for health and life-science industries, offering a wide range of apps for clinical data management, drug development, patient registries, biobank and lab management and more

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Dacima Clinical Suite logo

Electronic data capture solution

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Dacima's Clinical Suite ePCTR is carefully designed to provide unparalleled excellence in electronic data capture for clinical trials.

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Studypages logo

Cloud and mobile-based clinical research software

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Studypages is a cloud and mobile-based clinical research management platform that helps simplify clinical operations and connect participants, sites, and sponsors in one place.

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MainEDC logo

EDC, IWRS, Drug Supply, Logistic and ePRO Cloud Platform

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Configurable, compliant and reliable solution for impressive data capture results in clinical trials (integrated all-in-one EDC / IWRS / Drug Supply / ePRO cloud-based platform).

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DFdiscover logo

Clinical data management system for research organizations

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DFdiscover is a clinical data management system which helps academic and non-profit research organizations handle clinical trials, inventories, and remote adjudication processes. It enables researchers to upload case report forms and study documents, photos, and videos across existing data records.

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Encapsia logo

The game-changing EDC and eSource platform.

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Encapsia is THE best solution for the capture, management and reporting of EDC and eSource data in real-time.

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iMednet logo

Cloud-based electronic data capture (EDC) platform

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iMednet is a cloud-based electronic data capture (EDC) platform designed to help businesses manage clinical trials, inventories, and adjudication processes. Employees can utilize the built-in payment manager to view and approve payment requests and access patients’ transaction history in real-time.

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ClinVigilant eClinical logo

Cloud cost-effective platform to manage clinical trials

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Streamline your clinical studies, reduce set-up times and capture compliant data automatically from multiple sources with ClinVigilant eClinical. Simple, user-friendly & scalable tools.

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Labfront logo

All-in-one research solution for real-world data capture

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Labfront provides a code-free platform for the efficient collection of data from wearable and IoT devices. Researchers can conduct studies remotely, capture both subjective survey data and objective digital biomarker data, and collaborate seamlessly in real time.

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Trial Online logo

Clinical trial management software

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Trial Online is a clinical trial management software that helps businesses set up role-based access rights, manage derived calculations, monitor compliance, handle patient diaries, conduct audits, and more from within a unified platform. It allows staff members to segment patients based on data collected via events and questionnaires. It also lets employees configure reminders, maintain logbooks, and automatically receive safety and non-conformance alerts.

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