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Top Rated e-Prescribing Software with Mid size business

Last updated: October 2026

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39 software options

DxScript logo

HIPAA compliant prescribing solution

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DxScript/+EPCS is a HIPAA compliant, Surescripts and EPCS certified, cloud-based ePrescribing solution that puts insurance, pharmacy benefits plan eligibility and formulary information at the provider’s fingertips at the point of prescribing.

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MDToolbox-Rx logo

Surescripts & EPCS certified e-prescribing system

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MDToolbox e-Prescribing is a Surescripts & EPCS certified e-Prescribe software which can be used standalone on desktops, tablets, or phones, or integrated. MDToolbox offers a free 30 day no obligation trial and month-month or annual licensing.

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ScriptSure logo

Electronic prescribing software

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ScriptSure is a medical software for doctors, clinics and hospitals which supports e-prescribing, EMR management, appointment scheduling technology, and more

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Pabau logo

Practice management system for healthcare

Pabau is an all-in-one practice management software designed for healthcare businesses. The system offers digital patient records, online booking capabilities, calendar management, and integrated payment processing to streamline administrative workflows. Pabau also includes marketing tools, inventory management, and reporting features that help medical practices operate efficiently while maintaining secure patient data.

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TherapyNotes, LLC logo

Online mental health EMR and practice management software.

Web-based practice management & electronic health records (EHR) software for behavioral health with thousands of active users, and unlimited customer support.

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ModMed logo

Cloud-based EHR & practice platform for specialists

Cloud-based EHR, practice management, and RCM platform for specialty medical practices, with patient engagement and analytics tools.

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TriMed EHR logo

Integrated EHR, practice management and AI tools

TriMed is a customizable, cloud-based EHR and practice management platform for independent medical practices. It combines clinical, financial and patient engagement workflows with AI tools, mobile access, digital check-in, telemedicine and direct support from the team that develops the software.

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Alleva logo

We're the friendliest EMR platform around. Book a Demo!

Our state-of-the-art platform will take your center into the 21st century and streamline the entire process of EMR. Our platform provides more efficient workflows, reducing burn-out, and improving the quality of care. Insights offers real-time data for better business decisions and easier reporting.

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Qualifacts InSync EHR logo

Cloud-based EHR and practice management software.

Our EMR integrated e-prescribing is mobile-friendly for ease of access. Features include Eligibility and Formulary Checks, Medication History, EPCS, ePA, RTPB and APPRISS Integration for PMDP Checking. The end result is more accurate, easily-filled prescriptions for you and your practice.

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epocrates logo

Clinical reference and decision support tool

Epocrates is the essential clinical reference and decision support tool for healthcare professionals. Users can get access to thousands of drugs and their side effects, dosing information, and patient-facing content, which helps physicians prescribe safely and accurately.

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iCare logo

Focus on patient care, not software.

iCare is a cloud-based medical scheduling solution, which helps small to large healthcare organizations manage patient care plans, electronic health records, lab results, and more. The platform offers various features such as custom workflows, financial insights, compliance management, third-party integration, and pre-made templates.

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NovoClinical logo

Electronic medical record solution for private practices.

NovoClinical is a cloud-based electronic medical record (EMR) solution, which assists small to large medical practices with appointment scheduling and e-prescribing. Key features include compliance tracking, customized reporting, voice recognition, clinic interoperability, and timesheet management.

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iClinic logo

Medical practice management solution with EMR

iClinic is a medical practice management solution that is available in Portuguese and offered in Brazil. The platform is designed to help businesses with teleconsultation, online marketing, calendar management, and electronic medical records.

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Speed Script logo

Innovative Pharmacy Systems and Reliable Technology Services

Scalable pharmacy systems and technology you can count on. Flexible to work with you on your specific needs. Go beyond tools for prescription processing. Speed Scripts provides you with patient relationship management tools, MedSync, Workflow, POS, Inventory incl. 340B, LTC solution, and more.

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RXNT logo

Certified Clinical Healthcare & Practice Management Software

RXNT's cloud-based E-Prescribing solution is EPCS-certified and allows providers to easily, accurately write prescriptions from anywhere. Streamline your practice with a seamless connection to our EHR, and get instant access to medical and prescription history from a single platform.

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Treat logo

Standalone, ePrescribing solution for medical practitioners

Treat is an ePrescribing solution that allows medical practitioners to send electronic prescriptions to manage patient care and streamline clinical operations. Users can select specific drugs according to patient diagnosis and add digital signatures to generate prescriptions.

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Covetrus vRxPro logo

Prescription management software for veterinary clinics

Covetrus® vRxPro® is the only complete business solution that actively helps you compete with online retailers. Covetrus is committed to your growth and brings you closer than ever to your patients.

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HARMONY Medical logo

Fully integrated HIPPA compliant practice management and EHR

Harmony is a fully integrated HIPPA, ONC, JCAHO, CARF compliant practice management software with color-coded scheduling, comprehensive insurance and patient billing

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H2H DigitalRx logo

by H2H Solutions

H2H Digital Rx is a surescript-certified HIPAA-compliant cloud-based e-prescribing solution that helps healthcare professionals manage patient medication history, formulary, and refills. Features include EPCS, PDMP, RTPB, EPA, favorite Drugs, prescription templates, and many more.

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Semble logo

Cloud-based clinic management system

Semble is a cloud-based clinic management system, that helps healthcare practices manage patient data and administrative tasks, generate invoices, and process payments. Features include reminders, task allocation, questionnaire creation, access control, activity log, and user management.

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Intergy logo

Enterprise EHR & practice management with mobile app support

Greenway’s electronic health record (EHR) and practice management platform Intergy offers a user-friendly, specialty-focused solution for ambulatory healthcare practices. It provides tools to manage chronic conditions, capture payer incentives, and thrive in the world of value-based healthcare.

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SecureRx logo

Cloud-based print management software for healthcare clinics

SecureRx is a print management software designed to help healthcare organizations and ambulatory facilities create & securely print medical prescriptions in compliance with the state & federal regulations. Users can add anti-alteration watermarks in documents & serialize prescriptions for auditing.

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Enablemypractice logo

Cloud-based EHR solution for medical professionals.

Enablemypractice is an EHR (electronic health record) solution, which helps small to large healthcare organizations manage patient engagement, online billing, appointment schedules, medicine databases, and more. The platform provides several features such as communication tools, visit management, artificial intelligence (AI), reporting, electronic prescriptions, chronic care management (CCM), custom templates, live chat, mobile application, and bed management.

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Meddbase logo

Improving business efficiency, security, and patient care.

A fully-secure and scalable healthcare management solution empowering businesses to improve efficiency, security and patient care. Covering; booking, clinical, billing, communications, analytics and support modules, Meddbase is securely accessed from any web-enabled device, anywhere any time.

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CharmHealth logo

AI-based healthcare platform for medical practices

CharmHealth is an AI-based healthcare platform offering electronic health records, practice management, and medical billing solutions for medical practices of all sizes. The system features an AI scribe that automates documentation during patient encounters and integrates with pharmacies, labs, and devices. The platform includes patient engagement tools that allow individuals to schedule appointments, access records, and manage their healthcare information.

Read more about CharmHealth

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