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Top Rated Endpoint Protection Software with Mid size business

Last updated: May 2026

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164 software options

Jamf Protect logo

Jamf Protect

Endpoint protection software for MacOS users

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Jamf Protect is an endpoint protection software designed to help businesses monitor events across Mac devices and detect, prevent and resolve threats. The platform notifies administrators about malicious activities across scripts, applications, and users and automatically quarantines files for further analysis.

Features of Jamf Protect include log forwarding, CIS benchmarks, on-device activity analysis, threat intelligence, behavioral analytics, and more.

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ManageEngine Endpoint Central logo

ManageEngine Endpoint Central

Desktop, mobile device & patch management software

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Endpoint Central (formerly Desktop Central) from ManageEngine is an integrated desktop & mobile device management application that enables the centralized management of desktops, servers, laptops, tablets & smartphones.

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Heimdal Next-Gen Endpoint Antivirus logo

Heimdal Next-Gen Endpoint Antivirus

Next-Gen Antivirus for Unparalleled Detection and Response.

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Heimdal Next-Gen Endpoint Antivirus is an NGAV solution featuring unparalleled threat intelligence, forensics, and firewall integration for a complete endpoint detection and response approach. With it, you will not only secure your workstations but make everyone’s life easier in the process too.

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JumpCloud Directory Platform logo

JumpCloud Directory Platform

A cloud directory platform for secure access to resources

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JumpCloud is an open directory platform for secure, frictionless access from any device to any resource, anywhere.

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Netwrix Endpoint Policy Manager logo

Netwrix Endpoint Policy Manager

Real Policy. Real Control. Everywhere.

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Instantly secure endpoints by removing local admin rights, managing USB sticks, creating application firewalls, managing apps and operating system settings no matter where your users are. Increase what your GPO or MDM system can do!

Read more about Netwrix Endpoint Policy Manager

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Automox logo

Automox

Cloud-based platform for patch management

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Automox is the endpoint management platform built for the era of autonomous operations

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Netwrix Endpoint Protector logo

Netwrix Endpoint Protector

Data loss prevention and endpoint protection tool

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Netwrix Endpoint Protector is a data loss prevention tool which assists businesses of all sizes with data encryption and file scanning. Key features of the platform include compliance management and reporting, policy management, device control, and sensitive data identification.

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Shinobi Defense System logo

Shinobi Defense System

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Data loss prevention software

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Shinobi Defense System is a data loss prevention software that helps businesses manage whitelisting, set up automatic data encryption, configure internet access restrictions, and more from within a unified platform. It allows staff members to utilize the built-in search and filter functionality to consolidate and view log events and unexpected events across multiple endpoints.

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Heimdal Ransomware Encryption Protection logo

Heimdal Ransomware Encryption Protection

An Advanced Ransomware Encryption Blocking Agent.

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Heimdal Ransomware Encryption Protection is an innovative, 100% signature-free module that provides market-leading detection of ransomware attacks, as well as remediation in case of encryption. It is effective against both fileless and file-based strains, quietly securing all your digital assets.

Read more about Heimdal Ransomware Encryption Protection

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Iru logo

Iru

Collapse the IT stack with Iru.

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AI-powered platform that unifies identity, endpoints, and compliance—giving IT teams time and control back.

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Tanium logo

Tanium

Autonomous IT, driven by AI and real-time intelligence

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The Tanium Autonomous IT Platform unifies endpoint management and security on a single, unified platform. Real time endpoint intelligence and AI driven automation deliver continuous visibility, control, and closed loop action across IT, cloud, mobile, and OT - accelerating decisions, lowering costs,

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NinjaOne logo

NinjaOne

Unified endpoint management & IT automation platform

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NinjaOne Endpoint Management enables IT organizations of all sizes and experience levels to take a more proactive approach to IT management, which yields significant efficiency gains, improved user satisfaction and a stronger security posture.

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ManageEngine EventLog Analyzer logo

ManageEngine EventLog Analyzer

Web-Based SIEM & Log Management Solution. Affordable Prices.

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EventLog Analyzer is a web-based security information and event management (SIEM) solution, which assists small to large organizations with the monitoring of network devices, servers and applications. Key features include auditing, traffic analysis, threat detection, and compliance management.

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Acronis Cyber Protect Cloud logo

Acronis Cyber Protect Cloud

AI-powered data protection and cybersecurity

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Acronis Cyber Protect Cloud is AI-powered cyber protection for modern MSPs, natively integrating operations management, cybersecurity and data protection in one platform.

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Acronis Cyber Protect logo

Acronis Cyber Protect

Integrated data protection and cybersecurity in one solution

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Acronis Cyber Protect brings together data protection and cybersecurity in one, easy-to-use solution.

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Rippling logo

Workforce management across HR, finance, and IT. 

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Rippling is a cloud-based workforce management system that helps businesses manage operations across HR, finance, and IT.

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Action1 logo

Patching That Just Works

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Action1 reinvents patch management with an infinitely scalable and highly secure platform configurable in 5 minutes that just works.

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1Password logo

Password manager for businesses and families

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1Password protects all company secrets such as passwords, security tokens, 2FA codes, documents, and passkeys to centralize and simplify the sign-in experience. Developers have access to features that help secure secrets and speed up workflows throughout the software development life cycle.

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AccessPatrol by CurrentWare logo

Device control software - secure data from illicit transfers

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Device control software. Enforce the exclusive use of authorized peripheral devices. Block USB portable storage devices and restrict file transfers to protect sensitive data against theft.

Read more about AccessPatrol by CurrentWare

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GoodAccess logo

Zero Trust Architecture as a Service

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Cybersecurity platform (SASE/SSE) that enables easy Zero Trust Architecture implementation for medium enterprises, any scale.

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UTunnel VPN logo

Cloud VPN, Zero Trust Network Access, and Mesh Networking

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UTunnel offers easy-to-deploy Cloud VPN, Zero Trust Access, and Mesh Networking solutions. Safeguard your business with secure remote access and encrypted site-to-site connectivity between distributed business networks. Deployment in minutes, Robust Support, and Affordable Pricing Plans!

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ThreatLocker logo

Zero Trust Platform

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ThreatLocker is a Zero Trust platform that blocks unknowns, enforces least privilege, and protects endpoints from cyber threats.

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Admin By Request logo

Local admin rights, managed.

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Endpoint privilege management with just-in-time admin elevation, full auditing, and secure remote access for Windows, macOS, and Linux. Anti-malware file scanning, SSO and MFA enforcement, ML and AI automation, temporary local admin accounts, and a full inventory and detailed auditlog.

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SentinelOne logo

Protect your Endpoints, Cloud, and Data

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SentinelOne delivers autonomous cybersecurity powered by AI, enabling real-time prevention, detection, and response to threats across endpoints, cloud workloads, and identity systems—empowering organizations to stay ahead of cyberattacks with speed, visibility, and control.

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GateKeeper Enterprise logo

Shared PC authentication, proximity, 2FA/MFA wireless token.

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GateKeeper Enterprise is an access management software which helps businesses in healthcare, manufacturing, and other industries handle proximity-based authentication for PCs and websites. It enables organizations to automatically lock employees’ unattended devices and securely store passwords.

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