LOVE the ticketing; the ability to track a task from beginning to end is great. Unlike email; everything is in one place and all the messages/notes are together.
Teamwork Desk has amazing features. The automated responses and customization to the ticketing system and help doc area are superior to other help desk/ticket software.
Having used a number of PM solutions, I feel Teamwork is probably the best value for the money, between licensing, features, rock star responsive support, usability and ease of use.
It is a little confusing how to properly integrate with Projects. And once a project is closed in Teamwork it doesn't automatically close the ticket.
Integration was fairly simple though STMP error was not easy to uncover at first, but was very easy to fix once discovering this was an error. Lack of control over automation.
There is no automatic after hours feature that you can set a time frame to label tickets that come in during non office hours.