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Clinical Trial Management Software with Electronic Signature (2026)

Last updated: March 2026

Key features of Clinical Trial Management Software

Based on GetApp's analysis of verified user reviews collected between July 2021 and August 2024.

  • 21 CFR Part 11 Compliance: Reviewers emphasize the importance of 21 CFR Part 11 compliance for secure, trustworthy electronic records and signatures, ensuring regulatory adherence. 99% of reviewers rated this feature as important or highly important.
  • HIPAA Compliant: Users value HIPAA compliance for safeguarding patient privacy and maintaining ethical standards in clinical research. 96% of reviewers rated this feature as important or highly important.
  • Audit Trail: An effective audit trail feature helps users track changes, ensuring transparency and compliance during audits. 96% of reviewers rated this feature as important or highly important.
  • Electronic Data Capture: Reviewers appreciate real-time data capture, reducing errors and improving efficiency in clinical trials. 94% of reviewers rated this feature as important or highly important.
  • Document Management: Users highlight the ease of organizing, uploading, and retrieving documents, which streamlines regulatory inspections and daily operations. 94% of reviewers rated this feature as important or highly important.
  • Clinical Study Management: Reviewers find it essential for tracking study progress, managing sites, and ensuring data integrity throughout clinical trials. 92% of reviewers rated this feature as important or highly important.
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35 software options

Castor EDC logo

The top-rated EDC system in the world *EDC + ePRO + eConsent

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The only GCP & 21 CFR compliant system that's affordable for every researcher and has all the features of expensive systems. Start now.

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Visual Planning logo

Resource management, scheduling and planning solution

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Visual Planning supports clinical trial operations with centralized scheduling, resource allocation, and compliance tracking. Manage investigator meetings, patient visits, and equipment availability to ensure smooth trial execution and regulatory adherence.

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Viedoc logo

Electronic data capture for clinical trials

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Viedoc delivers powerful eClinical solutions that streamline clinical trials, making data collection, management, and analysis faster and easier. Trusted in 75+ countries, powering 7,000+ studies with more than 1.6M+ participants.

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Researchmanager – Clinical Research Suite logo

EDC, CTMS, eTMF, ePRO, RTSM, eConsent, RIMS, LIMS

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The Clinical Research Suite is an online platform tailored for managing clinical trials, facilitating organizations in planning, strategizing, and executing life science research. It empowers researchers to collect and analyze data in standardized formats, optimizing scientific research and decisio

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ShareCRF logo

EDC software for clinical research

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Take control of your clinical trial data with ShareCRF. Configure your study in hours—no coding or external help needed. Enjoy an intuitive interface, full regulatory compliance, and unmatched adaptability to fit your unique study needs. Simplicity, efficiency, and reliability in one platform.

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Medrio logo

Powering your research potential.

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Medrio is an electronic data capture (EDC) tool for clinical research teams with tools for capturing, storing, analyzing, & managing patient data during clinical trials. Medrio offers secure storage of patient data, automates regulatory compliance management & allows users to build custom studies.

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OpenClinica logo

Driving the future of clinical trials. Better data, faster.

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OpenClinica is a compliant, all-in-one clinical data management platform offering electronic data capture with collaborative drag and drop interface for designing studies, randomization and supply management, patient reported outcomes (ePRO & eCOA), plus reporting tools with chart visualizations

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eClinPro CTMS & eSource logo

Clinical trials made simple, compliant, and efficient

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eClinPro CTMS & eSource is a clinical trial management system (CTMS) that helps research centers manage clinical studies.

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TrialKit logo

Unified eClinical platform with embedded intelligence

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TrialKit is a global, cloud-based development platform for end-to-end, "direct-from-source" data collection and workflow management across all phases of clinical trials.

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ClinCapture logo

Clinical trial platform for research teams

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Captivate is a clinical trial management platform that offers multiple integrated modules for conducting research studies. The software includes electronic data capture, electronic patient-reported outcomes, electronic consent, randomization and trial supply management, electronic trial master file, and medical coding capabilities. Captivate is designed to support organizations involved in clinical research operations.

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CRIO logo

Clinical research regulatory workflow management software

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CRIO, the leader in eSource technology, is a health tech company helping pharma, biotech, research sites, and academic research centers streamline regulatory workflows with one system that delivers a single source of clinical data capture.

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Health Cloud logo

Patient relationship management software in the cloud

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Salesforce Health Cloud is a collaborative, all-round healthcare CRM and patient management software for healthcare providers, payers, and patients

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Prelude EDC logo

Clinical trial management system for researchers

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Prelude EDC is a web-based EDC solution that helps researchers and clinicians with clinical trial management. Key features include electronic data capture, data management, project management, custom fields, audit trail, automatic notifications, and compliance management.

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Climedo  logo

Powerful, modular and secure solutions for DCTs.

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Climedo is a secure and modular cloud-based electronic data capture (EDC) tool for decentralized clinical trials. It enables the clinical validation and post-market surveillance of of medtech and pharma products using tools such as cOA/ePRO, eCRF, clinical study tracking, input forms, etc.

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Datacapt logo

One unified Platform. Datacapt is reimagining your Trials.

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Datacapt is an intuitive and easy-to-use EDC platform with eCRF, ePRO, eConsult, and eConsent. Access real-rime reports, high-quality data capture, and fully compliant.

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Medicai logo

AI-Powered Medical Imaging Infrastructure & Healthcare APIs

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Manage imaging in clinical research with centralized access, standardized reporting, audit trails, and secure cross-site collaboration. Streamlines investigator review and sponsor communication.

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Agatha Applications logo

Solution for clinical and quality operations

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Agatha provides a suite of applications for biotech, pharmaceutical, and medical device companies to manage their processes. Agatha applications include Solution Manager, Formulary Management, Quality Control Reporting, Clinical Research Management and Regulatory Compliance.

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UnitusTI logo

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EMR, Practice Management, behavioral, educational and mental health data collection software including curricula.

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STARLIMS logo

Clinical trial management software for laboratories

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STARLIMS is a laboratory information management system that helps businesses interpret and manage clinical data. The platform enables managers to handle clinical trials, research and development (R&D), and manufacturing processes.

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Flex Databases platform logo

Unified platform for handling clinical trials and documents

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One system for clinical development process and beyond. Scalable and flexible CTMS with all the features you may need. Cloud based and on-premises options. Validated and complaint with regulations.

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MainEDC logo

EDC, IWRS, Drug Supply, Logistic and ePRO Cloud Platform

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Cloud-based EDC, IWRS, Drug Supply, Logistic, ePRO, Registries, PharmMarketing, eConsent, eCOA, eSource easy-to-use and powerful integrated platform.

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SimpleTrials CTMS/eTMF logo

Web-based CTMS & eTMF Solution

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SimpleTria is a web-based Clinical Trial Management System (CTMS) designed to support the biotechnology, pharmaceutical and device industries. It provides intuitive, project management tools that bridge clinical expertise with technical expertise in software development. SimpleTria provides a flexible, scalable, and easily adaptable eClinical management system which will improve study management efficiencies and reduce operating costs.

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DFdiscover logo

Clinical data management system for research organizations

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DFdiscover is a clinical data management system which helps academic and non-profit research organizations handle clinical trials, inventories, and remote adjudication processes. It enables researchers to upload case report forms and study documents, photos, and videos across existing data records.

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iMednet logo

Cloud-based electronic data capture (EDC) platform

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iMednet is a cloud-based electronic data capture (EDC) platform designed to help businesses manage clinical trials, inventories, and adjudication processes. Employees can utilize the built-in payment manager to view and approve payment requests and access patients’ transaction history in real-time.

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Complion logo

Clinical trial management software

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Complion is a document and workflow management software that focuses on automating investigator regulatory compliance to enable accelerated study startup and on-demand monitoring. Administrators can activate, train, and support investigators and study teams on demand. Teams can maintain monitor-ready regulatory or site files

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