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Digital Signature Software with HIPAA Compliant (2026)

Last updated: March 2026

Key features of Digital Signature Software

Based on GetApp's analysis of verified user reviews collected between July 2021 and August 2024.

  • Electronic Signature: Reviewers value the flexibility, security, and efficiency of signing documents remotely, saving time and ensuring legal compliance. 96% of reviewers rated this feature as important or highly important.
  • Data Security: Users highlight the importance of encryption and access controls to protect sensitive information and ensure confidentiality. 93% of reviewers rated this feature as important or highly important.
  • Multi-Party Signing: Reviewers appreciate the ability to quickly gather multiple signatures from different parties, enhancing efficiency and collaboration. 90% of reviewers rated this feature as important or highly important.
  • Authentication: Users find multiple authentication methods crucial for securing document access and ensuring signer identity verification. 89% of reviewers rated this feature as important or highly important.
  • Mobile Signature Capture: Reviewers enjoy the convenience of signing documents on mobile devices, increasing flexibility for on-the-go transactions. 88% of reviewers rated this feature as important or highly important.
  • Audit Trail: Users value detailed records of document activities, ensuring accountability and compliance with legal standards. 79% of reviewers rated this feature as important or highly important.
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26 software options

PandaDoc logo

PandaDoc

Cloud-based tool for creating, editing and signing documents

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Save time and boost your productivity with Electronic Signatures. Now you can send, sign, and approve documents faster than ever. Reduce the length of your sales cycle and give customers a better experience with legally binding eSignatures.

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Documo logo

Documo

Cloud-based solution for streamlining fax operations

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mFax is now Documo. With Documo, integrate eSignatures into your fax and document workflows. Documo routes documents for electronic signature, reducing turnaround times and enhancing security—all within one solution. Connected workflow: enable faxes to be routed and signed. Scalable: easily increase

Read more about Documo

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Buzz logo

Buzz

Patient-Centric Care - Maximize Efficiency, Minimize Burnout

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Transformative patient-centric care coordination platform that helps users improve healthcare provider collaboration through HIPAA-compliant text, documents, reports, and forms sharing in a patient-driven grouping model. It allows multiple channels of communication like SMS, fax, email, and bridging with EHR.

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Box logo

AI-driven content, collaboration and workflow management

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Box is a content cloud and AI-enabled platform that enables businesses to securely manage, collaborate on, and automate workflows for their content. It offers end-to-end data protection, seamless collaboration both internally and externally, and AI-powered features to extract insights from unstructured data and streamline critical business processes.

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Jotform logo

Cloud-based form builder tool for digital forms.

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Jotform Sign is the automated e-signature experience designed to streamline your workflow. With field detection, an intuitive builder, and integrations with great automation tools, Jotform Sign is the most efficient way to collect e-signatures.

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iLovePDF logo

Document generation and management software

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Sign, send, and track documents securely with advanced digital signatures, audit trails, and customizable branding for a professional touch. Part of a suite of 25+ tools, it also supports editing, OCR, and more—available on Mobile, Desktop, and with API automation.

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pdfFiller logo

Online PDF form filler & editor

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pdfFiller is an online form and document management system for editing, printing, downloading, sending, and converting documents. The cloud-based system offers eSignature capabilities, a PDF editor, form builder, authentication features, and native Android and iOS mobile applications.

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Revver logo

Cloud based, dynamic document-work management system

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Revver automates document-centric work and enables document-work collaboration. It is built for financial service organizations, insurance companies, and back-office departments across many industries, including healthcare, manufacturing, social care, IT, and many others.

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Nitro PDF logo

Document generation and management software

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Sign any document, on any device, from anywhere with Nitro’s secure and compliant eSignature software. Expedite contracts, support remote work, ensure regulatory compliance and track all your eSignatures in real time. Nitro Sign makes eSignature processes fast, easy, and affordable.

Read more about Nitro PDF

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Progress ShareFile logo

Secure file sharing and sync

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Progress ShareFile provides users with the ability to send, receive and share large business files securely. Through the ShareFile portal, offer clients a personalized, company-branded and password-protected platform from which to collaborate on files.

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Jotform Sign logo
Category Leaders

Powerful Forms Get It Done

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Jotform Sign is the automated e-signature experience designed to streamline your workflow. With field detection, an intuitive builder, and integrations with great automation tools, Jotform Sign is the most efficient way to collect e-signatures.

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GoFormz logo

Capture better data with digital forms

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Send, sign, and approve documents faster than ever, with GoFormz. Digitize your existing paper or PDF forms and use them to collect legally binding eSignatures from anyone, anywhere. Signed forms can be automatically routed to clients or uploaded to connected systems, like Salesforce or Box.

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123FormBuilder logo

Web forms: as easy as 1-2-3!

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123FormBuilder is the quickest solution for creating professional forms for both web and mobile. With its easy drag-and-drop form editor, you can build custom contact forms, surveys, registration forms, and order forms in minutes—right from your browser. No coding skills are needed.

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Fluix logo

Field work done right 

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Your field team can fill out, annotate & sign documents on mobile, get customer e-signatures through any device and send the completed contracts to back office

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PlatoForms logo

Cloud-based tool for creating and managing PDFs

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PlatoForms is a versatile tool that simplifies PDF form creation and management, enhances collaboration, ensures data security, and drives productivity. By leveraging PlatoForms, businesses can streamline their operations, reduce administrative burdens, and focus on their core operations.

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FormAssembly logo

Forms in a Flash. Secure data collection made simple.

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FormAssembly is an easy-to-use, powerful web form and data collection platform. We help organizations get rid of inefficient data collection methods, streamline and connect their data with smart integrations, and reduce reliance on IT and development services.

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Conga Contracts logo

Automate and simplify contract management in Salesforce

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Sign documents quickly and securely, save money, and
reduce risk—all while creating an easy, efficient experience for your customers.

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OnBase logo

Enterprise content management solution

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Automate & integrate the management and control of documents, business processes & records using one application

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eFax logo

Secure online fax-by-email service

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eFax is an online fax service which allows companies to send and receive faxes via email on their computer, tablet, and smartphone. eFax Protect, our highly encrypted online fax plan provides a comprehensive solution for businesses seeking both compliance and security in their fax communications.

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Content Central logo

On-premise & in-cloud document management software

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Eliminate repetitive and tedious processes with Content Central’s powerful workflow engine and integrations, intelligently sort and store your documents, and ensure eSignatures and forms are filed or sent securely and on-time with unmatched automation and compliance tools.

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Hushmail logo

Email, web form, and e-signature solution for healthcare

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Hushmail is a web-based email, web form, and e-signature service that enables businesses to send and receive encrypted client communications. The drag-and-drop form builder, template directory, and integrated e-signatures are perfect for healthcare, legal, and other fields requiring confidentiality.

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FormDr logo

Software for creating, sharing, and managing digital forms

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FormDr is a cloud-based software that allows organizations to create, send and receive HIPAA-compliant forms via a centralized portal. The platform allows users to share custom forms with patients, enabling them to sign via their phone, tablet, or desktop.

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AFAS Software logo

Human resources, payroll, and finance management

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AFAS Software is a suite of tools that automates processes for human resources, payroll, & finance management, providing personalized access to the platform for both employees & managers. AFAS features include automated invoice reconciliation, leave and absence registration, payroll analysis & more.

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MeSign logo
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End-to-End encryption and digital signature app for emails.

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Provides email encryption, digital signing and timestamping service for your corporate emails.

Auto-configure email certificates, encrypt email message automatically by default with S/MIME standard.

Cloud and on-premise key management are both supported.

Read more about MeSign

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Confidencial logo
(0)

Cloud-based data protection and security solution

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Confidencial is a cloud-based document security solution that enables users to protect sensitive data with granular encryption controls.

Read more about Confidencial

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